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Molecular immune pathogenesis and diagnosis of COVID-19

Identifieur interne : 000468 ( 2020/Analysis ); précédent : 000467; suivant : 000469

Molecular immune pathogenesis and diagnosis of COVID-19

Auteurs : Xiaowei Li [République populaire de Chine] ; Manman Geng [République populaire de Chine] ; Yizhao Peng [République populaire de Chine] ; Liesu Meng [République populaire de Chine] ; Shemin Lu [République populaire de Chine]

Source :

RBID : PMC:7104082

Abstract

Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia with an unusual outbreak in Wuhan, China, in December 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The emergence of SARS-CoV-2 has been marked as the third introduction of a highly pathogenic coronavirus into the human population after the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) in the twenty-first century. In this minireview, we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection.


Url:
DOI: 10.1016/j.jpha.2020.03.001
PubMed: 32282863
PubMed Central: 7104082


Affiliations:


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PMC:7104082

Le document en format XML

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<p>Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia with an unusual outbreak in Wuhan, China, in December 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The emergence of SARS-CoV-2 has been marked as the third introduction of a highly pathogenic coronavirus into the human population after the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) in the twenty-first century. In this minireview, we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection.</p>
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